منابع مشابه
ElemeNT: a computational tool for detecting core promoter elements
Core promoter elements play a pivotal role in the transcriptional output, yet they are often detected manually within sequences of interest. Here, we present 2 contributions to the detection and curation of core promoter elements within given sequences. First, the Elements Navigation Tool (ElemeNT) is a user-friendly web-based, interactive tool for prediction and display of putative core promot...
متن کاملThe unexpected traits associated with core promoter elements.
The core promoter of eukaryotic coding and non-coding genes that are transcribed by RNA polymerase II (RNAP II) is composed of DNA elements surrounding the transcription start site. These elements serve as the docking site of the basal transcription machinery and have an important role in determining the position and directing the rate of transcription initiation. This review summarizes the cur...
متن کاملFunctional characterization of core promoter elements: the downstream core element is recognized by TAF1.
Downstream elements are a newly appreciated class of core promoter elements of RNA polymerase II-transcribed genes. The downstream core element (DCE) was discovered in the human beta-globin promoter, and its sequence composition is distinct from that of the downstream promoter element (DPE). We show here that the DCE is a bona fide core promoter element present in a large number of promoters an...
متن کاملGluonic Pole Matrix Elements and Universality
We investigate the spectral properties of quark-quark-gluon correlators and use this to study gluonic pole matrix elements. Such matrix elements appear in principle both for distribution functions such as the Sivers function and fragmentation functions such as the Collins function. We find that for a large class of spectator models, the contribution of the gluonic pole matrix element for fragme...
متن کاملClassification of Promoters Based on the Combination of Core Promoter Elements Exhibits Different Histone Modification Patterns.
Four different histones (H2A, H2B, H3, and H4; two subunits each) constitute a histone octamer, around which DNA wraps to form histone-DNA complexes called nucleosomes. Amino acid residues in each histone are occasionally modified, resulting in several biological effects, including differential regulation of transcription. Core promoters that encompass the transcription start site have well-con...
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ژورنال
عنوان ژورنال: Nature
سال: 2014
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature13587